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HIGHLIGHTED ARTICLES FROM ANNALS OF SURGICAL ONCOLOGY

Weekly Update

Survival Outcomes and Genetic Characteristics of Resected Pancreatic Acinar Cell Carcinoma. 

May 30, 2025

Citation: Blair, A.B., Radomski, S.N., Chou, J. et al. Survival Outcomes and Genetic Characteristics of Resected Pancreatic Acinar Cell Carcinoma. Ann Surg Oncol 32, 1869–1878 (2025). https://doi.org/10.1245/s10434-024-16331-4
Synopsis: This multi-institutional series of resected pancreatic acinar cell carcinoma (pACC) reports a median overall survival of >70 months. Mutations within the homologous recombination repair (HRR) pathway were identified in 45%, with core HRR mutations in 26% suggesting opportunities for informed targeted therapeutic options for pACC.

The Impact of Diagnostic Laparoscopy on Upstaging Patients with Siewert II and III Gastroesophageal Junction (GEJ) Cancer. 

May 30, 2025

Citation: Alcasid, N.J., Fink, D., Banks, K.C. et al. The Impact of Diagnostic Laparoscopy on Upstaging Patients with Siewert II and III Gastroesophageal Junction (GEJ) Cancer. Ann Surg Oncol 32, 258–264 (2025). https://doi.org/10.1245/s10434-024-15862-0
Synopsis: There remains little consensus regarding the efficacy of diagnostic laparoscopy for Siewert II gastroesophageal junction (GEJ) cancers. Compared to Siewert III cancers, routine diagnostic laparoscopy and cytology in Siewert II cancer does not affect the upstaging rate, delays definitive treatment, with no improvement in survival.
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Speaking of SurgOnc Speaking of SurgOnc® is a podcast brought to you by the Annals of Surgical Oncology (ASO) and the Society of Surgical Oncology (SSO).

The series is hosted by ASO Deputy Editor Dr. Frederick L. (Rick) Greene, who expands upon ideas from articles published in the Annals. Once a month, Dr. Greene will interview authors and leading experts in surgical oncology.

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ASO is the journal of choice of surgical oncologists and cancer multidisciplinary teams worldwide regarding surgical oncology research and education, and benefits surgeons, oncologists, hematologists, radiologists, general practitioners, pathologists, researchers, academicians, and other clinical professionals interested in all aspects of the surgical treatment of cancer. ASO strives to improve the practice environment in which high-quality surgical oncology care is delivered, to enhance the quality of life and survival of the surgical patient with cancer.

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