Featured Articles Archive

Citation: Stoop, T.F., Seelen, L.W.F., van ’t Land, F.R. et al. Nationwide Use and Outcome of Surgery for Locally Advanced Pancreatic Cancer Following Induction Chemotherapy. Ann Surg Oncol (2023). https://doi.org/10.1245/s10434-023-14650-6

Synopsis: This study assessed the nationwide use and outcome of resection of locally advanced pancreatic cancer (LAPC) following induction chemo(radio)therapy. Results demonstrated that surgery for LAPC following induction chemo(radio)therapy was performed infrequently in the 16 Dutch centers for pancreatic surgery averaging only four resections per center over a seven-year period. Given these findings, a structured nationwide approach involving international centers of excellence would be needed to improve selection of patients with LAPC for surgical resection following induction therapy.

Citation: Holmberg, CJ., Mikiver, R., Isaksson, K. et al. Prognostic Significance of Sentinel Lymph Node Status in Thick Primary Melanomas (> 4 mm). Ann Surg Oncol 30, 8026–8033 (2023). https://doi.org/10.1245/s10434-023-14050-w

Synopsis: Using a large prospective national cohort, this study confirms that sentinel lymph node (SLN) status gives important prognostic information for patients in the thick (>4mm) melanoma subgroup. We recommend that current clinical guidelines be updated to reflect this prognostic value.

Citation: Griffin, C., Fairhurst, K., Stables, I. et al. Outcomes of Women Undergoing Mastectomy for Unilateral Breast Cancer Who Elect to Undergo Contralateral Mastectomy for Symmetry: A Systematic Review. Ann Surg Oncol 31, 303–315 (2024). https://doi.org/10.1245/s10434-023-14294-6 

Synopsis: Contralateral mastectomy for ‘flat symmetry’ after unilateral mastectomy for breast cancer is an alternative to reconstruction but surgeons fear women may experience decisional regret. This review demonstrates patients are satisfied with their decision, supporting surgeons to offer women this option.

Citation: Rodriguez-Quintero, J.H., Kamel, M.K., Jindani, R. et al. The Effect of Neoadjuvant Therapy on Esophagectomy for cT2N0M0 Esophageal Adenocarcinoma. Ann Surg Oncol 31, 228–238 (2024). https://doi.org/10.1245/s10434-023-14441-z 

Synopsis: For cT2N0M0 esophageal adenocarcinomas, the benefits of neoadjuvant chemoradiotherapy prior to esophagectomy are debatable. In this study, the authors investigate 1) the perioperative impact of NT on esophagectomy and 2) the oncologic effect of NT in a homogenous group of patients with clinical stage IIA (T2N0M0) esophageal adenocarcinoma.

Citation: Hübner, M., van Der Speeten, K., Govaerts, K. et al. 2022 Peritoneal Surface Oncology Group International Consensus on HIPEC Regimens for Peritoneal Malignancies: Colorectal Cancer. Ann Surg Oncol 31, 567–576 (2024). https://doi.org/10.1245/s10434-023-14368-5

Synopsis: Based on the available evidence, despite the negative results of PRODIGE 7, HIPEC could be conditionally recommended to patients with peritoneal metastases of colorectal cancer after cytoreductive surgery (CRS). While more preclinical and clinical data are eagerly awaited to harmonize the procedure further, the mitomycin-C–based Dutch protocol remains the preferred regimen after primary and secondary CRS.

Citation: Blumencranz, P., Habibi, M., Shivers, S. et al. The Predictive Utility of MammaPrint and BluePrint in Identifying Patients with Locally Advanced Breast Cancer Who are Most Likely to Have Nodal Downstaging and a Pathologic Complete Response After Neoadjuvant Chemotherapy. Ann Surg Oncol 30, 8353–8361 (2023). https://doi.org/10.1245/s10434-023-14027-9 

Synopsis: The authors evaluated the association between MammaPrint (70-gene risk of distant metastasis signature) and BluePrint (80-gene molecular subtyping signature) and nodal downstaging. A significantly greater proportion of patients with MammaPrint High Risk and BluePrint HER2 and Basal tumors had nodal downstaging.

Citation: Khan, S.Y., Cole, J., Habrawi, Z. et al. Cryoablation Allows the Ultimate De-escalation of Surgical Therapy for Select Breast Cancer Patients. Ann Surg Oncol 30, 8398–8403 (2023). https://doi.org/10.1245/s10434-023-14332-3

Synopsis: This study documents the account of ultimate de-escalation 72 of breast and axillary surgery in select patients utilizing cryoablation.

Citation: Söderström, H., Moons, J., Nafteux, P. et al. Major Intraoperative Complications During Minimally Invasive Esophagectomy. Ann Surg Oncol 30, 8244–8250 (2023). https://doi.org/10.1245/s10434-023-14340-3 

Synopsis:  This study reports major intraoperative complications encountered during minimally invasive esophagectomy for cancer. Complication data from 2862 patients was collected retrospectively from 10 esophageal surgery centers. We report 101 complications in 98 patients, types of repairs and mortality. 

Citation: Gjorup, C.A., Woodford, R., Li, I. et al. Role of Concurrent Ultrasound Surveillance of Sentinel Node-Positive Node Fields in Melanoma Patients Having Routine Cross-Sectional Imaging. Ann Surg Oncol (2023). https://doi.org/10.1245/s10434-023-14526-9

Synopsis: In sentinel node-positive melanoma patients in whom CLND was omitted, node field recurrence only occurred in 5%. Nodal recurrences were detected frequently on cross-sectional imaging.

Citation: Cano Garcia, C., Tappero, S., Piccinelli, M.L. et al. In-Hospital Venous Thromboembolism and Pulmonary Embolism After Major Urologic Cancer Surgery. Ann Surg Oncol 30, 8770–8779 (2023). https://doi.org/10.1245/s10434-023-14246-0

Synopsis: After major urological cancer surgeries, venous thromboembolism (VTE) rates increased while pulmonary embolism (PE) rates decreased. radical cystectomy (RC), radical nephrectomy (RN) and partial nephrectomy (PN) surgeries were associated with higher VTE and PE risk than radical prostatectomy (RP). Patients with VTE or PE exhibited higher mortality after RC and RN.

Citation: Verheij, F.S., Kuhlmann, K.F.D., Silliman, D.R. et al. Combined Hepatic Arterial Infusion Pump and Systemic Chemotherapy in the Modern Era for Chemotherapy-Naive Patients with Unresectable Colorectal Liver Metastases. Ann Surg Oncol 30, 7950–7959 (2023). https://doi.org/10.1245/s10434-023-14073-3

Synopsis: Combined hepatic artery infusion and modern systemic therapy in chemotherapy-naive patients with unresectable CRLM resulted in durable and substantial response in a large proportion of patients. The majority of patients proceeded to conversion surgery, which was associated with prolonged survival.

Citation: Hakki, L., Khan, A., Gonen, M. et al. Lymph Node Metastases and Associated Recurrence-Free Survival in Microsatellite Stable and Unstable Colon Cancer. Ann Surg Oncol 30, 8487–8494 (2023). https://doi.org/10.1245/s10434-023-14270-0

Synopsis: Lymph node metastasis (LNM) are 50% less prevalent in MSI colon cancer compared to MSS subtype, but factors associated with LNM are similar among both subtypes. The improved prognosis associated with early-stage MSI colon cancers dissipates with 4 or more LNM.

Citation: Zwart, K., van der Baan, F.H., Punt, C.J.A. et al. Survival of Patients with Deficient Mismatch Repair Versus Proficient Mismatch Repair Metastatic Colorectal Cancer Receiving Curative-Intent Local Treatment of Metastases in a Nationwide Cohort. Ann Surg Oncol 30, 6762–6770 (2023). https://doi.org/10.1245/s10434-023-13974-7

Synopsis: This nationwide study presents recurrence-free and overall survival after curative-intent local treatment of metastases in the distinct subgroup of deficient mismatch repair metastatic colorectal cancer and demonstrates comparable to more favorable outcomes compared to proficient mismatch repair tumors.

Citation: Ramalingam, K., Clelland, E., Rothschild, H. et al. Successful Breast Conservation After Neoadjuvant Chemotherapy in Lobular Breast Cancer: The Role of Menopausal Status in Response to Treatment. Ann Surg Oncol 30, 7099–7106 (2023). https://doi.org/10.1245/s10434-023-14075-1

Synopsis: Menopausal status does not predict successful breast conservation surgery after neoadjuvant chemotherapy (NAC) in invasive lobular carcinoma (ILC). Pre-menopausal patients receive more NAC, but response rates are similar, suggesting the need for improved predictors and treatments for ILC.

Citation: Cabrera, S., Gómez-Hidalgo, N.R., García-Pineda, V. et al. Accuracy and Survival Outcomes after National Implementation of Sentinel Lymph Node Biopsy in Early Stage Endometrial Cancer. Ann Surg Oncol 30, 7653–7662 (2023). https://doi.org/10.1245/s10434-023-14065-3

Synopsis: The implementation of sentinel lymph node biopsy for early-stage endometrial cancer in a clinical setting yields high sensitivity for detecting nodal disease. A high volume of patients with micrometastases and isolated tumor cells will be diagnosed, and tailoring adjuvant treatments will be key to achieve excellent oncologic outcomes. 

Citation: Arya, S., Ventin, M., Nebbia, M. et al. Long-Term Outcomes of Tuberous Sclerosis Complex-Associated Non-functional Pancreatic Neuroendocrine Tumors: Should We Be More Conservative?. Ann Surg Oncol 30, 7748–7755 (2023). https://doi.org/10.1245/s10434-023-14157-0

Synopsis: The current study evaluates the clinical course of patients who have undergone surgical resection of their pancreatic neuroendocrine tumors (PNETs), specifically comparing the disease course of tuberous sclerosis complex-PNETs to patients with nonfunctional sporadic-PNETs.

Citation: Raoof, M., Whelan, R.L., Sullivan, K.M. et al. Safety and Efficacy of Oxaliplatin Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) in Colorectal and Appendiceal Cancer with Peritoneal Metastases: Results of a Multicenter Phase I Trial in the USA. Ann Surg Oncol 30, 7814–7824 (2023). https://doi.org/10.1245/s10434-023-13941-2 

Synopsis: Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) is a repeatable, laparoscopic procedure for locoregional drug delivery in the treatment of peritoneal metastases. This phase 1 trial demonstrates safety, feasibility, and early efficacy of oxaliplatin PIPAC in colorectal and appendiceal cancer peritoneal metastases.

Citation: Tsekrekos, A., Borg, D., Johansson, V. et al. Impact of Laparoscopic Gastrectomy on the Completion Rate of the Perioperative Chemotherapy Regimen in Gastric Cancer: A Swedish Nationwide Study. Ann Surg Oncol 30, 7196–7205 (2023). https://doi.org/10.1245/s10434-023-13967-6

Synopsis: This nationwide study examined whether laparoscopic gastrectomy for gastric cancer has a positive impact on different aspects of the completion of the perioperative chemotherapy. The results do not support that a minimally invasive approach has a substantial beneficial effect. 

Citation: Rhodin, K.E., Tyler, D.S., Zager, J.S. et al. Great Debate: Limb Infusion for Melanoma: A Thing of the Past? Ann Surg Oncol 30, 6319–6324 (2023). https://doi.org/10.1245/s10434-023-13765-0

Synopsis: In transit melanoma (ITM) remains heterogeneous in presentation, progression, and outcomes. Such variability can often make the treatment of ITM complex. The authors highlight a debate on the role of limb infusion in the contemporary management of advanced melanoma.

Citation: Munck, F., Jepsen, P., Zeuthen, P. et al. Comparing Methods for Targeted Axillary Dissection in Breast Cancer Patients: A Nationwide, Retrospective Study. Ann Surg Oncol 30, 6361–6369 (2023). https://doi.org/10.1245/s10434-023-13792-x 

Synopsis: Targeted axillary dissection is often done with a two-marker combination. Difficulties in re-marking the lymph node affect 16% of patients, and the success of excision of the marked lymph node varies with marking method. Two-step TAD success is 82.3%.

Citation: Sattar, A.K., Masroor, T., Martins, R.S. et al. Impact of Postoperative Antibiotic Prophylaxis on Surgical Site Infections Rates After Mastectomy with Drains but Without Immediate Reconstruction: A Multicenter, Double-Blinded, Randomized Control Superiority Trial. Ann Surg Oncol 30, 5965–5973 (2023). https://doi.org/10.1245/s10434-023-13887-5

Synopsis: The authors explored the utility of continued postoperative antibiotic prophylaxis (PAP) in reducing surgical site infection (SSI) rates after mastectomy without immediate reconstruction and with indwelling drains.

Citation: Al-Hilli, Z., Noss, R., Dickard, J. et al. A Randomized Trial Comparing the Effectiveness of Pre-test Genetic Counseling Using an Artificial Intelligence Automated Chatbot and Traditional In-person Genetic Counseling in Women Newly Diagnosed with Breast Cancer. Ann Surg Oncol 30, 5990–5996 (2023). https://doi.org/10.1245/s10434-023-13888-4

Synopsis: The feasibility of providing expanded genetic counseling services for patients with breast cancer is limited by resource availability. An artificial intelligence model (Chatbot) provides an alternative service delivery method for pre-test genetic counseling with comparable patient satisfaction and comprehension.

Citation: Bond, M.J.G., Kuiper, B.I., Bolhuis, K. et al. Intersurgeon Variability in Local Treatment Planning for Patients with Initially Unresectable Colorectal Cancer Liver Metastases: Analysis of the Liver Expert Panel of the Dutch Colorectal Cancer Group. Ann Surg Oncol 30, 5376–5385 (2023). https://doi.org/10.1245/s10434-023-13510-7

Synopsis: Evaluation of a liver expert panel in the phase III randomised CAIRO5 study showed considerable variability among liver surgeons in prospective resectability assessments and local treatment planning for patients with initially unresectable colorectal liver metastases who received induction systemic therapy.

Citation: Raichurkar, P., Denehy, L., Solomon, M. et al. Research Priorities in Prehabilitation for Patients Undergoing Cancer Surgery: An International Delphi Study. Ann Surg Oncol (2023). https://doi.org/10.1245/s10434-023-14192-x

Synopsis: The authors employ an international Delphi study to achieve consensus amongst an international multidisciplinary team of surgeons, anesthetists, nurses, and allied health staff to identify the top research priorities in prehabilitation for patients undergoing cancer surgery.

Citation: Rothschild, H.T., Clelland, E.N., Mujir, F. et al. Predictors of Early Versus Late Recurrence in Invasive Lobular Carcinoma of the Breast: Impact of Local and Systemic Therapy. Ann Surg Oncol 30, 5999–6006 (2023). https://doi.org/10.1245/s10434-023-13881-x

Synopsis:  Invasive carcinoma (ILC) is known for high cumulative late recurrence risk, which makes surveillance a clinical priority. In a multivariable analysis of ILC cases from an institutional database, different factors and treatment received were associated with timing of recurrence.

Citation: Sposito, C., Maspero, M., Conalbi, V. et al. Impact of Indocyanine Green Fluorescence Imaging on Lymphadenectomy Quality During Laparoscopic Distal Gastrectomy for Gastric Cancer (Greeneye): An Adaptative, Phase 2, Clinical Trial. Ann Surg Oncol 30, 6803–6811 (2023). https://doi.org/10.1245/s10434-023-13848-y

Synopsis:  In this Simon two-stage phase II study, preoperative peritumoral ICG injection and subsequent completion lymphadenectomy improved the quality of D2 lymphadenectomy during laparoscopic distal gastrectomy.

Citation: Ogobuiro, I., Collier, A.L., Khan, K. et al. Racial Disparity in Pathologic Response following Neoadjuvant Chemotherapy in Resected Pancreatic Cancer: A Multi-Institutional Analysis from the Central Pancreatic Consortium. Ann Surg Oncol 30, 1485–1494 (2023). https://doi.org/10.1245/s10434-022-12741-4

Synopsis:  In a multi-institutional retrospective study of 486 pancreatic cancer patients undergoing pancreatectomy following neoadjuvant therapy, Black race is associated with significantly reduced odds of major pathologic response. 

Citation: Murimwa, G.Z., Karalis, J.D., Meier, J. et al. Hospital Designations and Their Impact on Guideline-Concordant Care and Survival in Pancreatic Cancer. Do They Matter?. Ann Surg Oncol 30, 4377–4387 (2023). https://doi.org/10.1245/s10434-023-13308-7MD 

Synopsis:  The authors compare the significance of four hospital designations on guideline concordant care (GCC) and survival (OS) of patients treated for pancreatic ductal adenocarcinoma (PDAC). Treatment at NCI designated (NCI), high-volume (HV) hospitals correlated with improved GCC and survival. Including GCC as a metric in accreditation standards could impact survival for PDAC patients.

Citation: Soon, J.J.Y., Juan, D.W.K., Ong, W.S. et al. Implementation of a Multi-Disciplinary Team and Quality of Goals of Care Discussions in Palliative Surgical Oncology Patients. Ann Surg Oncol (2023). https://doi.org/10.1245/s10434-023-14190-z 

Synopsis: The implementation of a multi-disciplinary palliative surgical intervention team was associated with an improvement in the quality of goals of care discussions amongst advanced cancer patients undergoing palliative interventions at the authors’ institution.

Citation: Gerwing, M., Schindler, P., Katou, S. et al. Multi-organ Radiomics-Based Prediction of Future Remnant Liver Hypertrophy Following Portal Vein Embolization. Ann Surg Oncol (2023). https://doi.org/10.1245/s10434-023-14241-5

Synopsis: In this study, a radiomic feature assessment of the liver, spleen and bone marrow identified three radiomic features in baseline CT data to predict the standardized future remnant liver hypertrophy after portal vein embolization.

Maki, H., Ayabe, R.I., Nishioka, Y. et al. Hepatectomy Before Primary Tumor Resection as Preferred Approach for Synchronous Liver Metastases from Rectal Cancer. Ann Surg Oncol 30, 5390–5400 (2023). https://doi.org/10.1245/s10434-023-13656-4 

Synopsis: The reverse approach for synchronous rectal cancer liver metastases is associated with comparable survival to the classic and combined approaches and may obviate proctectomies/diversions. RAS/TP53 co-mutation is associated with a lower completion rate of the reverse approach.

Vemuru, S.R., Bronsert, M., Vossler, K. et al. Postoperative Outcomes After Staged Versus Coordinated Breast Surgery and Bilateral Salpingo-Oophorectomy. Ann Surg Oncol 30, 5667–5680 (2023). https://doi.org/10.1245/s10434-023-13630-0 

Synopsis: In this review of 4,228 patients who underwent both breast surgery and bilateral salpingooophorectomy, staged operations were associated with similar healthcare costs but lower rates of postoperative complications compared to coordinated operations, an effect most evident among those whose breast operation was a mastectomy.

Citation: Verreck, E.E.F., van Steenhoven, J.E.C., Kuijer, A. et al. Trends of Axillary Treatment in Sentinel Node-Positive Breast Cancer Patients Undergoing Mastectomy. Ann Surg Oncol 30, 5623–5632 (2023). https://doi.org/10.1245/s10434-023-13568-3 

Synopsis: The ACOSOG-Z0011- and the AMAROS-trial obviated the need for axillary surgery in most sentinel node-positive (SLN+) breast cancer patients undergoing breast conserving surgery. In this study in SLN+ patients undergoing mastectomy, use of axillary surgery decreased drastically over time.

Citation: Casella, F., Bencivenga, M., Brancato, G. et al. Bidirectional Approach with PIPAC and Systemic Chemotherapy for Patients with Synchronous Gastric Cancer Peritoneal Metastases (GCPM). Ann Surg Oncol 30, 5733–5742 (2023). https://doi.org/10.1245/s10434-023-13572-7

Synopsis: This study evaluates the efficacy of PIPAC with systemic chemotherapy as bidirectional approach for Gastric Cancer (GC) patients with Synchronous Peritoneal Metastases (SPM).

Citation: Maki, H., Ayabe, R.I., Nishioka, Y. et al. Hepatectomy Before Primary Tumor Resection as Preferred Approach for Synchronous Liver Metastases from Rectal Cancer. Ann Surg Oncol 30, 5390–5400 (2023). https://doi.org/10.1245/s10434-023-13656-4 

Synopsis:  The reverse approach for synchronous rectal cancer liver metastases is associated with comparable survival to the classic and combined approaches and may obviate proctectomies/diversions. RAS/TP53 co-mutation is associated with a lower completion rate of the reverse approach.

Citation: Sluckin, T.C., Hazen, SM.J.A., Horsthuis, K. et al. Evaluation of National Surgical Practice for Lateral Lymph Nodes in Rectal Cancer in an Untrained Setting. Ann Surg Oncol 30, 5472–5485 (2023). https://doi.org/10.1245/s10434-023-13460-0

Synopsis:  Consensus is lacking regarding the type of surgical treatment required for malignant lateral lymph nodes (LLNs) in rectal cancer. This cross-sectional multicenter study found that 64 patients in the Netherlands in 2016 underwent additional LLN-surgery, resulting in four-year lateral local recurrence rates of 14-20%.

Citation: Davey, M.G., Temperley, H.C., O’Sullivan, N.J. et al. Minimally Invasive and Open Gastrectomy for Gastric Cancer: A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials. Ann Surg Oncol 30, 5544–5557 (2023). https://doi.org/10.1245/s10434-023-13654-6

Synopsis: The authors report on a network meta-analysis of randomized clinical trials comparing outcomes after open (OG), laparoscopic-assisted (LAG), and robotic gastrectomy for gastric cancer. This analysis demonstrates the non-inferiority of oncological and surgical outcomes for OG and LAG in patients being treated predominantly for early gastric cancer following at 5 years follow-up.

Citation: Bhatt, A., Glehen, O., Zivanovic, O. et al. The 2022 PSOGI International Consensus on HIPEC Regimens for Peritoneal Malignancies: Epithelial Ovarian Cancer. Ann Surg Oncol (2023). https://doi.org/10.1245/s10434-023-13932-3

Synopsis: An expert panel of over 70 gynecological and surgical oncologists voted on 38 key questions regarding the use of HIPEC in epithelial ovarian cancer. The recommendations should guide clinical practice and direct future research.

Citation: Scholfield, D.W., Fitzgerald, C.W., Alzumaili, B. et al. Diffuse Sclerosing Papillary Thyroid Carcinoma: Clinicopathological Characteristics and Prognostic Implications Compared with Classic and Tall Cell Papillary Thyroid Cancer. Ann Surg Oncol 30, 4761–4770 (2023). https://doi.org/10.1245/s10434-023-13589-y 

Synopsis: Diffuse sclerosing papillary thyroid carcinoma characteristically presents with large volume nodal metastases and lymphatic invasion. Almost half of patients develop recurrence despite aggressive initial management. Despite this, disease specific survival is excellent.

Citation: Knotts, C.M., Osman, M.A., Aderonmu, A.A. et al. Defining the Values and Quality of Life of Cancer Survivors Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: An International Survey Study. Ann Surg Oncol (2023). https://doi.org/10.1245/s10434-023-14034-w 

Synopsis: This study investigated the quality of life and values of patients with cancer who underwent CRS±HIPEC. Despite long-term impairments, quality of life improved over time and is similar to other surgery survivors. Survivors prioritized longevity and independence over experience and cost.

Citation: Fasano, G.A., Bayard, S., Chen, Y. et al. Survival Outcomes in Women with Unilateral, Triple-Negative, Breast Cancer Correlated with Contralateral Prophylactic Mastectomy. Ann Surg Oncol 30, 4648–4656 (2023). https://doi.org/10.1245/s10434-022-13056-0 

Synopsis: Contralateral prophylactic mastectomy (CPM) does not improve survival among women with unilateral triple negative breast cancer (TNBC) without BRCA mutations. Further study is needed to evaluate potential benefit of CPM among TNBC patients with BRCA mutations.

Citation: Al-Sukhni, E., Shapiro, J., Suraweera, H. et al. Desmoid Tumors in Familial Adenomatous Polyposis Patients: Favorable Outcomes with Multidisciplinary Management. Ann Surg Oncol 30, 5142–5149 (2023). https://doi.org/10.1245/s10434-023-13675-1 

Synopsis: Familial adenomatous polyposis (FAP) associated desmoid tumors represent a distinct subset of desmoid disease with potentially significant morbidity and mortality. We describe the characteristics, management, and outcomes of a group of FAP patients with desmoid tumors treated at our high-volume sarcoma center. 

Citation: Gudmundsdottir, H., Habermann, E.B., Vierkant, R.A. et al. Survival and Symptomatic Relief After Cytoreductive Hepatectomy for Neuroendocrine Tumor Liver Metastases: Long-Term Follow-up Evaluation of More Than 500 Patients. Ann Surg Oncol 30, 4840–4851 (2023). https://doi.org/10.1245/s10434-023-13372-z 

Synopsis: In this study, the authors describe their 20-year institutional experience with cytoreductive hepatectomy in over 500 patients with neuroendocrine tumor liver metastases, including perioperative outcomes, rates of symptom relief in patients with functional tumors, and long-term overall and progression-free survival.

Citation: Swartjes, H., van Rees, J.M., van Erning, F.N. et al. Locally Recurrent Rectal Cancer: Toward a Second Chance at Cure? A Population-Based, Retrospective Cohort Study. Ann Surg Oncol 30, 3915–3924 (2023). https://doi.org/10.1245/s10434-023-13141-y 

Synopsis: Three-year cumulative incidence of locally recurrent rectal cancer (LRRC) was 6.4%. More than 40% of LRRC patients received curative-intent treatment. Three-year overall survival after curative-intent treatment was 70%. The impact of prior neoadjuvant treatment on LRRC outcomes seems limited.

Citation: van Hemert, A.K.E., van Duijnhoven, F.H., van Loevezijn, A.A. et al. Biopsy-Guided Pathological Response Assessment in Breast Cancer is Insufficient: Additional Pathology Findings of the MICRA Trial. Ann Surg Oncol 30, 4682–4689 (2023). https://doi.org/10.1245/s10434-023-13476-6 

Synopsis: This pathology sub-study quantifies the residual disease remaining after neoadjuvant systemic therapy in breast cancer patients with a favorable response on MRI as well as residual disease missed with 14G biopsies. Substantial residual invasive disease was missed in all subtypes which may hamper local control and limits adjuvant systemic treatment options. Therefore, surgical excision remains obligatory until accuracy of imaging and biopsy techniques improve.

Citation: Augustinus, S., Schafrat, P.J.M., Janssen, B.V. et al. Nationwide Impact of Centralization, Neoadjuvant Therapy, Minimally Invasive Surgery, and Standardized Pathology Reporting on R0 Resection and Overall Survival in Pancreatoduodenectomy for Pancreatic Cancer. Ann Surg Oncol 30, 5051–5060 (2023). https://doi.org/10.1245/s10434-023-13465-9 

Synopsis:  In this nationwide cohort study in 2955 patients after pancreatoduodenectomy (PD) for pancreatic cancer the R0 resection rate decreased over time (2009-2019), mostly related to more complete pathology reporting, but remained associated with improved overall survival.

Citation: Kwak, H.V., Tardy, K.J., Allbee, A. et al. Surgical Management of Germline Gastrointestinal Stromal Tumor. Ann Surg Oncol 30, 4966–4974 (2023). https://doi.org/10.1245/s10434-023-13519-y 

Synopsis: Germline mutations causing gastrointestinal stromal tumors (GISTs) are rare and surgical management of some of these patients is controversial. The authors discuss this controversy and highlight key concepts in a patient with a germline KIT 579 deletion.

Citation: Bryan, A.F., Castillo-Angeles, M., Minami, C. et al. Value of Ambulatory Modified Radical Mastectomy. Ann Surg Oncol 30, 4637–4643 (2023). https://doi.org/10.1245/s10434-023-13588-z

Synopsis:  Though oncologic breast surgery is often ambulatory, modified radical mastectomy (MRM) is still frequently an inpatient procedure. The authors used population-level data to reveal that ambulatory MRM patients were readmitted less often, and the procedure was less expensive in the ambulatory setting. Ambulatory MRM should be performed for the appropriate patients.

Citation: Schell, F., Kefleyesus, A., Benzerdjeb, N. et al. Influence of Extraperitoneal Metastases on the Curative-Intent Management of Colorectal Peritoneal Metastases. Ann Surg Oncol 30, 4444–4454 (2023). https://doi.org/10.1245/s10434-023-13279-9

Synopsis: In a retrospective analysis of the impact of extra-peritoneal metastases on curative-intent management of colorectal patients with peritoneal metastases, the combined resection of liver metastases did not lead to decreased survival, while retroperitoneal lymph nodes and/or two extra-peritoneal metastatic sites impaired the prognosis.

Citation: Improta, L., Pasquali, S., Iadecola, S. et al. Organ Infiltration and Patient Risk After Multivisceral Surgery for Primary Retroperitoneal Liposarcomas. Ann Surg Oncol 30, 4500–4510 (2023). https://doi.org/10.1245/s10434-023-13314-9 

Synopsis:  This study investigated histologic organ involvement (HOI) in patients with retroperitoneal liposarcomas. HOI was a frequent finding, supporting the need for multivisceral surgery. HOI revealed itself as an independent predictor of outcome, suggesting its factoring in patients’ risk stratification.

Citation:

Frederiks, C.N., Overwater, A., Bergman, J.J.G.H.M. et al. Feasibility and Safety of Tailored Lymphadenectomy Using Sentinel Node-Navigated Surgery in Patients with High-Risk T1 Esophageal Adenocarcinoma. Ann Surg Oncol 30, 4002–4011 (2023). https://doi.org/10.1245/s10434-023-13317-6 

Synopsis: This study investigates the feasibility and safety of a new treatment algorithm for patients with high-risk T1 esophageal adenocarcinoma, consisting of a radical endoscopic resection of the tumor followed by tailored lymphadenectomy using sentinel node-navigated surgery with a hybrid tracer of technetium-99m nanocolloid and indocyanine green.

Citation:

Zhan, P.L., Canavan, M.E., Ermer, T. et al. Association Between Metastatic Pattern and Prognosis in Stage IV Gastric Cancer: Potential for Stage Classification Reform. Ann Surg Oncol 30, 4180–4191 (2023). https://doi.org/10.1245/s10434-023-13287-9

Synopsis:  9% of stage IV gastric cancer patients present with distant disease limited to nonregional lymph nodes. They are managed similarly to other stage IV patients but experience a better prognosis, suggesting opportunities to introduce M1 staging subclassifications for gastric cancer.

Citation:

Eshmuminov, D., Aminjonov, B., Palm, R.F. et al. FOLFIRINOX or Gemcitabine-based Chemotherapy for Borderline Resectable and Locally Advanced Pancreatic Cancer: A Multi-institutional, Patient-Level, Meta-analysis and Systematic Review. Ann Surg Oncol 30, 4417–4428 (2023). https://doi.org/10.1245/s10434-023-13353-2 

Synopsis: The primary aim of this meta-analysis was to assess the impact of primary chemotherapy, FOLFIRINOX or gemcitabine-based chemotherapy regimens, on survival rates of patients with borderline resectable pancreas cancer and locally advanced pancreas cancer.

Citation:

Munck, F., Andersen, I.S., Vejborg, I. et al. Targeted Axillary Dissection with ¹²⁵I Seed Placement Before Neoadjuvant Chemotherapy in a Danish Multicenter Cohort. Ann Surg Oncol (2023). https://doi.org/10.1245/s10434-023-13432-4 

Synopsis: Targeted axillary dissection varies in methodology, but using ¹²⁵I seeds without re-marking before surgery shows an excellent identification rate with detection of the sentinel node comparable to literature. This spares 41% of patients a redundant axillary dissection.

Citation:

Vega, E.A., Newhook, T.E., Mellado, S. et al. Benchmarks and Geographic Differences in Gallbladder Cancer Surgery: An International Multicenter Study. Ann Surg Oncol (2023). https://doi.org/10.1245/s10434-023-13531-2

Synopsis: Surgery for gallbladder cancer (GBC) is complex, requiring expertise, and associated with significant morbidity. The present study defines benchmark values, which represent the best achievable results in patients with GBC. Such values may help promote high-quality surgery and reach excellent oncologic care.

Citation:

Valenzuela, C.D., Solsky, I.B., Erali, R.A. et al. Long-Term Survival in Patients Treated with Cytoreduction and Heated Intraperitoneal Chemotherapy for Peritoneal Mesothelioma at a Single High-Volume Center. Ann Surg Oncol 30, 2666–2675 (2023). https://doi.org/10.1245/s10434-022-13061-3 

Synopsis: The authors report long-term survival data for patients with malignant peritoneal mesothelioma treated with cytoreduction and heated intraperitoneal chemotherapy. Analysis of a single institutional cohort (111 patients) identified key factors correlated with overall survival. The authors also report conditional survival in this context.

Choi, W.J., Ivanics, T., Gravely, A. et al. Optimizing Circulating Tumour DNA Use in the Perioperative Setting for Intrahepatic Cholangiocarcinoma: Diagnosis, Screening, Minimal Residual Disease Detection and Treatment Response Monitoring. Ann Surg Oncol 30, 3849–3863 (2023). https://doi.org/10.1245/s10434-023-13126-x

Synopsis: In this review, we present the current evidence and future perspectives on the use of circulating tumor DNA (ctDNA) in the diagnosis, management and understanding the prognosis of patients with intrahepatic cholangiocarcinoma undergoing surgery.

Tomiyama, T., Itoh, S., Iseda, N. et al. Clinical Significance of Signal Regulatory Protein Alpha (SIRPα) Expression in Hepatocellular Carcinoma. Ann Surg Oncol 30, 3378–3389 (2023). https://doi.org/10.1245/s10434-022-13058-y 

Synopsis: This study aimed to examine the clinical significance of SIRPα expression in HCC tumors using RNA-sequencing (RNA-seq) data from a public database and immunohistochemical data from a public database of patients who underwent surgical resection for HCC.

Nash, A.L., Hwang, E.S. The Landmark Series—Ductal Carcinoma in Situ: The Evolution of Treatment. Ann Surg Oncol 30, 3206–3214 (2023). https://doi.org/10.1245/s10434-023-13370-1

Synopsis: This review describes the landmark studies on which current DCIS management is based.

Hogg, M.E., Melstrom, L.G. Top Pancreatic Tumor Articles from 2021 to Inform Your Cancer Patients. Ann Surg Oncol 30, 3437–3443 (2023). https://doi.org/10.1245/s10434-023-13277-x

Synopsis: The publications highlighted in this review of 2021 articles are comprehensive on the current management of neoadjuvant therapy for resectable pancreatic cancer, the addition of radiation to neoadjuvant therapy for borderline resectable pancreatic cancer, the utility of arterial resections in unresectable pancreatic cancer, and the role of minimally invasive approach to pancreatic cancer surgical therapy.

Liu, D.S., Fayed, A., Evans, P. et al. Understanding Potentially Preventable Mortality Following Oesophago-Gastric Cancer Surgery: Analysis of a National Audit of Surgical Mortality. Ann Surg Oncol (2023). https://doi.org/10.1245/s10434-023-13571-8

Synopsis: Analysis of the Australian and New Zealand Audit of Surgical Mortality demonstrated that almost 50% of deaths following esophago-gastric cancer surgery were potentially preventable. These cases were characterized by higher rates of sepsis, multiorgan dysfunction syndrome, reoperations, and other complications. 

Williamson, C.G., Ebrahimian, S., Sakowitz, S. et al. Race, Insurance, and Sex-Based Disparities in Access to High-Volume Centers for Pancreatectomy. Ann Surg Oncol 30, 3002–3010 (2023). https://doi.org/10.1245/s10434-022-13032-8

Synopsis: High-volume centers for pancreatic cancer operations have superior clinical outcomes compared to lower-volume centers, but treat lower proportions of female, non-White, and Medicaid populations. These findings may have implications for improving access to high-quality centers for patients with this devastating disease.

Michiels, N., Doppenberg, D., Groen, J.V. et al. Intraoperative Ultrasound During Surgical Exploration in Patients with Pancreatic Cancer and Vascular Involvement (ULTRAPANC): A Prospective Multicenter Study. Ann Surg Oncol (2023). https://doi.org/10.1245/s10434-023-13112-3 

Synopsis: Intraoperative ultrasound is being used during surgical exploration in patients with pancreatic cancer and vascular involvement to assess resectability, especially following chemotherapy. In this study, intraoperative ultrasound changed the resectability status in 32/85 patients (38%), mainly downstaging (30/32 patients; 94%).

Berardi, G., Chou, J., Gonen, M. et al. A Model to Predict Treatment Failure in Patients Undergoing Upfront Surgery for Resectable Colorectal Liver Metastases. Ann Surg Oncol 30, 2820–2827 (2023). https://doi.org/10.1245/s10434-023-13113-2

Synopsis: 

This study aimed to investigate the outcomes of a large cohort of patients undergoing upfront surgery for resectable colorectal liver metastases (CRLM) and identify those experiencing early recurrence as a surrogate for a group who may be more likely to benefit from neoadjuvant chemotherapy or novel selection strategies.

Endo, Y., Sasaki, K., Moazzam, Z. et al. Higher Tumor Burden Status Dictates the Impact of Surgical Margin Status on Overall Survival in Patients Undergoing Resection of Intrahepatic Cholangiocarcinoma. Ann Surg Oncol 30, 2023–2032 (2023). https://doi.org/10.1245/s10434-022-12803-7

Synopsis: The objective of this study was to define the impact of resection margin status on long-term survival relative to overall intrahepatic cholangiocarcinoma (ICC)  tumor burden status. In particular, the authors assessed whether the prognostic significance of margin status, as well as wider margin width, varied based on ICC tumor burden score (TBS) and nodal status.

Citation:

Wilkerson, A.D., Obi, M., Ortega, C. et al. Young Black Women May be More Likely to Have First Mammogram Cancers: A New Perspective in Breast Cancer Disparities. Ann Surg Oncol 30, 2856–2869 (2023). https://doi.org/10.1245/s10434-022-12995-y 

Synopsis: 

Mammographic screening recommendations remain discordant. This study demonstrates that Black women may be more likely to have cancer detected on their first mammogram. It also highlights an association between first mammogram cancers, younger age and greater disease burden at diagnosis.

Citation:

Graversen, M., Detlefsen, S., Ainsworth, A.P. et al. Treatment of Peritoneal Metastasis with Pressurized Intraperitoneal Aerosol Chemotherapy: Results from the Prospective PIPAC-OPC2 Study. Ann Surg Oncol 30, 2634–2644 (2023). https://doi.org/10.1245/s10434-022-13010-0

Synopsis: Pressurized IntraPeritoneal Aerosol Chemotherapy is a safe treatment in patients with peritoneal metastasis. In the largest prospective, controlled study to date, the authors show that the Peritoneal Regression Grading score holds significant prognostic information.

Citation:

Sasaki, K., Ruffolo, L.I., Kim, M.H. et al. The Current State of Liver Transplantation for Colorectal Liver Metastases in the United States: A Call for Standardized Reporting. Ann Surg Oncol 30, 2769–2777 (2023). https://doi.org/10.1245/s10434-023-13147-6 

Synopsis: The interest in liver transplantation for metastatic colorectal cancer to the liver (CRLM) has exploded onto the transplant oncology scene. This study aimed to elucidate the current US situation using the United Network Organ Sharing (UNOS) database. Between December/2017-March/2022, 46 patients received transplants and their 3-year survival rate was 60.4%.

Citation:

Doyle, J.P., Patel, P.H., Doran, S.L.F. et al. The Cancer Hub Approach for Upper Gastrointestinal Surgery During COVID-19 Pandemic: Outcomes from a UK Cancer Centre. Ann Surg Oncol 30, 2266–2275 (2023). https://doi.org/10.1245/s10434-022-12571-4 

Synopsis: This article describes the operational set-up and favorable clinical outcomes when performing upper gastrointestinal cancer surgery via the dedicated “RM Partners Cancer Hub” approach during the COVID-19 pandemic.

Citation:

de Bakker, J.K., Suurmeijer, J.A., Toennaer, J.G.J. et al. Surgical Outcome After Pancreatoduodenectomy for Duodenal Adenocarcinoma Compared with Other Periampullary Cancers: A Nationwide Audit Study. Ann Surg Oncol 30, 2448–2455 (2023). https://doi.org/10.1245/s10434-022-12701-y

Synopsis: The aim of this multicenter, nationwide audit-based study was to determine the postoperative morbidity and mortality after pancreatoduodenectomy for duodenal adenocarcinoma compared to other periampullary cancers.

Citation:

Wei, A.C. Practice-Changing Evidence in Surgical Oncology 2021: Hepatobiliary Articles. Ann Surg Oncol 30, 1960–1965 (2023). https://doi.org/10.1245/s10434-023-13132-z 

Synopsis: The article highlights the best studies of the past year in hepatobiliary cancer and describes how this new evidence will impact clinical practice.

Citation:

Eden, C.M., Johnson, J., Syrnioti, G. et al. The Landmark Series: The Breast Cancer Burden of the Asian American Population and the Need for Disaggregated Data. Ann Surg Oncol 30, 2121–2127 (2023). https://doi.org/10.1245/s10434-023-13103-4

Synopsis: This Landmark Series article showcases the breadth of the breast cancer burden in the Asian American Pacific Islander (AAPI) population and highlights the need for disaggregated ethnic data. 

Citation:

Vallejos, P.A., Gonda, A., Yu, J. et al. Plasma Exosome Gene Signature Differentiates Colon Cancer from Healthy Controls. Ann Surg Oncol (2023). https://doi.org/10.1245/s10434-023-13219-7

Synopsis: Current liquid biopsy options lack sensitivity in peritoneal carcinomatosis (PC). In this initial feasibility analysis, we have identified a plasma exosome-based gene signature of 445 genes from colon cancer patients, including those with PC, that is distinct from healthy controls.

Citation:

Civil, Y.A., Jonker, L.W., Groot Koerkamp, M.P.M. et al. Preoperative Partial Breast Irradiation in Patients with Low-Risk Breast Cancer: A Systematic Review of Literature. Ann Surg Oncol (2023). https://doi.org/10.1245/s10434-023-13233-9

Synopsis: This systematic review shows that pre-operative partial breast irradiation is a feasible treatment option in patients with low-risk breast cancer. Pathologic complete response was reported in almost half of the patients with acceptable toxicity, good oncological and cosmetic outcomes.

Swartjes, H., van Lankveld, D.W.P., van Erning, F.N. et al. Locoregionally Recurrent Colon Cancer: How Far Have We Come? A Population-Based, Retrospective Cohort Study. Ann Surg Oncol 30, 1726–1734 (2023). https://doi.org/10.1245/s10434-022-12689-5

Synopsis: Three-year cumulative incidence of LRCC was 3.8%. Curative-intent treatment was given to nearly 30% of LRCC patients. Three-year overall survival after curative-intent treatment was 71%. Outcomes of LRCC in this study were excellent in comparison with literature.

Hussain, Z., Heaton, M.J., Snelling, A.P. et al. Risk Stratification of Sentinel Node Metastasis Disease Burden and Phenotype in Stage III Melanoma Patients. Ann Surg Oncol 30, 1808–1819 (2023). https://doi.org/10.1245/s10434-022-12804-6

Synopsis: An alternative staging system for micrometastatic SN+ stage III melanoma based on maximum tumor deposit size and extracapsular spread, consistently valid across pT1-pT4a melanomas, stratifying patients for either adjuvant systemic therapy or observation. The authors found no low-risk SN+ pT4b melanomas.

Citation:

Chen, J.W., van Ramshorst, T.M.E., Lof, S. et al. Robot-Assisted Versus Laparoscopic Distal Pancreatectomy in Patients with Resectable Pancreatic Cancer: An International, Retrospective, Cohort Study. Ann Surg Oncol (2023). https://doi.org/10.1245/s10434-022-13054-2

Synopsis: In this international multicenter retrospective cohort of patients with resectable pancreatic cancer, robot-assisted distal pancreatectomy appeared as oncologically safe as laparoscopic distal pancreatectomy in terms of R0-resection and survival rates. Although the lymph node yield and conversion rate appeared favorable after RDP, LDP was associated with shorter operating time, less major complications, and shorter hospital stay.

Citation:

Karakatsanis, A., Eriksson, S., Pistiolis, L. et al. Delayed Sentinel Lymph Node Dissection in Patients with a Preoperative Diagnosis of Ductal Cancer In Situ by Preoperative Injection with Superparamagnetic Iron Oxide (SPIO) Nanoparticles: The SentiNot Study. Ann Surg Oncol (2023). https://doi.org/10.1245/s10434-022-13064-0

Synopsis:  In this prospective cohort study of 254 women with DCIS, SPIO was injected in the breast to mark the SLN, but no upfront SLND was performed. In all, 78.3% avoided upfront SLND. In delayed SLND, SPIO outperformed the isotope in SLN detection (98.2% vs 63.6%, p<0.001).

Citation:

Pollini, T., Wong, P. & Maker, A.V. The Landmark Series: Intraductal Papillary Mucinous Neoplasms of the Pancreas—From Prevalence to Early Cancer Detection. Ann Surg Oncol 30, 1453–1462 (2023). https://doi.org/10.1245/s10434-022-12870-w

Synopsis: Intraductal Papillary Mucinous Neoplasms (IPMN) of the pancreas are the most common pancreatic cystic neoplasms, and are known predecessors of pancreatic adenocarcinoma.In this article, landmark data on IPMN prevalence, guidelines, surveillance, biomarkers, and

immune landscape are highlighted.

Citation:

Gholami, S., Colby, S., Horowitz, D.P. et al. Adjuvant Chemoradiation in Patients with Lymph Node-Positive Biliary Tract Cancers: Secondary Analysis of a Single-Arm Clinical Trial (SWOG 0809). Ann Surg Oncol 30, 1354–1363 (2023). https://doi.org/10.1245/s10434-022-12863-Synopsis:  Lymph node status is a strong predictor for recurrence in biliary cancers. A secondary analysis of S0809 was performed to estimate survival benefits of adjuvant chemoradiation based on nodal status in this population compared to historic controls.

Shaw, J.F., Budiansky, D., Sharif, F. et al. The Association of Frailty with Outcomes after Cancer Surgery: A Systematic Review and Metaanalysis. Ann Surg Oncol 29, 4690–4704 (2022). https://doi.org/10.1245/s10434-021-11321-2

Synopsis: Frailty is common among older adults. In this article, the authors systematically reviewed the association of frailty with adverse outcomes in older adults undergoing cancer surgery. Frailty was significantly associated with increased odds of postoperative mortality, complications, adverse discharge, and increased length-of-stay. 

Laws, A., Pastorello, R., Dey, T. et al. Impact of the Histologic Pattern of Residual Tumor After Neoadjuvant Chemotherapy on Recurrence and Survival in Stage I–III Breast Cancer. Ann Surg Oncol 29, 7726–7736 (2022). https://doi.org/10.1245/s10434-022-12054-6

Synopsis:  Slides from 666 patients treated with NAC and surgery underwent central pathology review to determine pattern of residual tumor and evaluate its prognostic significance. A scattered (relative to concentric) pattern of response was associated with inferior recurrence-free and overall survival.

Hunt, K.K., Suman, V.J., Wingate, H.F. et al. Local-Regional Recurrence After Neoadjuvant Endocrine Therapy: Data from ACOSOG Z1031 (Alliance), a Randomized Phase 2 Neoadjuvant Comparison Between Letrozole, Anastrozole, and Exemestane for Postmenopausal Women with Estrogen Receptor-Positive Clinical Stage 2 or 3 Breast Cancer. Ann Surg Oncol (2023). https://doi.org/10.1245/s10434-022-12972-5

Synopsis: ACOSOG Z1031 (Alliance) was designed to determine which aromatase inhibitor is most effective for postmenopausal women with estrogen receptor–positive stage 2 to 3 breast cancer in the neoadjuvant setting. The local-regional recurrence rate of 509 women is reported here.

McMullin, J.L., Sharma, J., Gillespie, T. et al. Improved Adherence to ATA Medullary Thyroid Cancer Treatment Guidelines. Ann Surg Oncol (2022). https://doi.org/10.1245/s10434-022-12734-3

Synopsis:  The 2009 ATA guidelines for medullary thyroid cancer were created to unify national practice patterns. Treatment was discordant from guidelines in 26% of cases after 2009 compared to 33% prior. Improved adherence to guidelines correlates with improved overall survival. 

Fonseca, A.L., Cherla, D., Kothari, A.N. et al. Association of Medicaid Expansion with Pancreatic Cancer Treatment and Outcomes: Evidence from the National Cancer Database. Ann Surg Oncol 29, 342–351 (2022). https://doi.org/10.1245/s10434-021-10709-4

Synopsis:  Medicaid expansion impacts access to treatment and outcomes in pancreatic cancer. In this cohort study of 41,486 patients with non-metastatic pancreatic adenocarcinoma in the National Cancer Database from 2006 to 2016, Medicaid expansion was associated with increased rates of curative intent surgical resection, multimodal therapy and treatment at high-volume facilities. Medicaid expansion was also associated with improved 30- day and 90-day survival and overall survival.

Allen, S.K., Brown, V., White, D. et al. Multimodal Prehabilitation During Neoadjuvant Therapy Prior to Esophagogastric Cancer Resection: Effect on Cardiopulmonary Exercise Test Performance, Muscle Mass and Quality of Life—A Pilot Randomized Clinical Trial. Ann Surg Oncol 29, 1839–1850 (2022). https://doi.org/10.1245/s10434-021-11002-0

Synopsis:  This randomized controlled trial demonstrates that multimodal prehabilitation can result in skeletal muscle and cardiopulmonary fitness (peak VO2) retention and improvements in quality of life in patients undergoing neoadjuvant therapy for locally advanced oesophagogastric cancer compared with control subjects.

Martins, M., Santos-Sousa, H., Araújo, F. et al. Impact of Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Gastric Cancer with Peritoneal Carcinomatosis: A Systematic Review and Meta-analysis. Ann Surg Oncol 29, 7528–7537 (2022). https://doi.org/10.1245/s10434-022-12312-7

Synopsis:  The main aim of this systematic review with meta-analysis is to compare the survival, postoperative complications, and peritoneal recurrence between cytoreductive surgery with hyperthermic intraperitoneal chemotherapy and cytoreductive surgery alone, in gastric cancer patients with peritoneal carcinomatosis.

Chichura, A., Attai, D.J., Kuchta, K. et al. Male Breast Cancer Patient and Surgeon Experience: The Male WhySurg Study. Ann Surg Oncol 29, 6115–6131 (2022). https://doi.org/10.1245/s10434-022-12135-6

Synopsis:  The authors report on survey results that found that men undergoing mastectomy without reconstruction are often dissatisfied with their cosmetic outcomes. Surgeons expressed willingness to perform breast conserving surgery and offer reconstruction to men with breast cancer, but less than half had experience.

van Veldhuisen, E., Klompmaker, S., Janssen, Q.P. et al. Surgical and Oncological Outcomes After Preoperative FOLFIRINOX Chemotherapy in Resected Pancreatic Cancer: An International Multicenter Cohort Study. Ann Surg Oncol (2022). https://doi.org/10.1245/s10434-022-12387-2

Synopsis:  This study comprising 423 patients with resected pancreatic cancer after preoperative FOLFIRINOX chemotherapy demonstrated a 38-month OS in patients with borderline resectable pancreatic cancer and 33 months in locally advanced pancreatic cancer. Neither the number of preoperative cycles nor the use of adjuvant therapy were associated with survival.

Nogueira, L.M., Palis, B., Boffa, D. et al. Evaluation of the Impact of the COVID-19 Pandemic on Reliability of Cancer Surveillance Data in the National Cancer Database. Ann Surg Oncol (2022). https://doi.org/10.1245/s10434-022-12935-w

Synopsis:  There was a decrease in the number of cancer cases reported to the National Cancer Database (NCDB) during 2020, the first year of the COVID-19 pandemic, reflecting changes in healthcare utilization during the lockdown rather than changes in data collection.

Citation: St. Amour, T.C., Demarchi, M.S., Thomas, G. et al. Educational Review: Intraoperative Parathyroid Fluorescence Detection Technology in Thyroid and Parathyroid Surgery. Ann Surg Oncol 30, 973–993 (2023). https://doi.org/10.1245/s10434-022-12807-3

Synopsis:  Image- and probe-based near-infrared autofluorescence detection systems can be used to identify in situ parathyroid glands. While these systems each possess their own benefits and pitfalls, both require the use of contrast enhancement (ICG) to differentiate viable from devascularized glands.

Citation: Khan, S., Doan, NH., Hosseini, M. et al. Is Routine Omentectomy a Necessary Component of Cytoreductive Surgery and HIPEC?. Ann Surg Oncol 30, 768–773 (2023). https://doi.org/10.1245/s10434-022-12714-7

Synopsis:  The incidence of occult histologic omental metastasis in this series was 31.9%. Patients with omentectomy had no higher morbidity than those without omentectomy, and 20.9% of patients with residual omentum later developed omental recurrence.