A Systematic Review of Occult Malignancy and Sentinel Lymph Node Metastasis at the Time of Contralateral Prophylactic Mastectomy
October 17, 2025.
Citation: Sturz-Ellis, J.L., Vetter, C.D., Day, C.N. et al. A Systematic Review of Occult Malignancy and Sentinel Lymph Node Metastasis at the Time of Contralateral Prophylactic Mastectomy. Ann Surg Oncol (2025). https://doi.org/10.1245/s10434-025-18474-4
Synopsis: Across 27 studies, 5728 patients underwent contralateral prophylactic mastectomy (CPM), with 87 occult malignancy (OM) identified. OM in CPM is uncommon (1.55%), and when it occurs, it is predominantly pT1, luminal A, invasive ductal carcinoma with a limited nodal burden.





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